The Department of Defense Injury Prevention and Performance Optimization Research Initiative began in 2006 with the US Army 101st Airborne (Air Assault) Division at Fort Campbell, KY. Based on the task and demand analyses, injury epidemiology, and laboratory testing, we identified sub-optimal musculoskeletal, physiological, and nutritional characteristics of the Soldiers. Using this information and considering the tactical demands of the Soldiers, the Eagle Tactical Athlete Program (ETAP) was developed and validated. Division-wide implementation of ETAP began in May 2009 utilizing the "Train the Trainer" strategy. The ETAP implementation utilized an Instructor Certification School (ICS), which was a 4-day school designed to teach Non-Commissioned Officers (NCOs) how to implement ETAP with their respective units. A systematic approach was implemented to monitor daily training exposure, track injuries, and monitor performance adaptations with the research objective to evaluate the effects of ETAP on reducing unintentional musculoskeletal injuries. At the result, the ETAP improved physical performance and reduced musculoskeletal injuries across a large cohort of the 101st Division Soldiers. The ETAP project was completed in Feb 2013.